Local Regulation of Homeostasis Favors Chromosomal Instability

Local Regulation of Homeostasis Favors Chromosomal Instability

Tissues of long-lived multicellular organisms have to maintain a constant number of functioning cells for many years. This process is called homeostasis. Homeostasis breaks down when cells emerge with mutations in tumor suppressor genes or oncogenes. Such mutated cells can have increased net rates of proliferation, which is increased somatic fitness. We show that the best protection against suc...

Local Regulation of Homeostasis Favors Chromosomal Instability [15–20]. A major question in cancer genetics is to what extent CIN is an early event and thus a driving force of tumorigenesis or a late-stage consequence [21–25]. CIN

[15–20]. A major question in cancer genetics is to what extent CIN is an early event and thus a driving force of tumorigenesis or a late-stage consequence [21–25]. CIN fitness. The selective cost of CIN, however, can be overcome by an increased probability of generating muta-Fukuoka 812-8581 Japan tions, such as LOH of TSP genes, that enhance the fitness of the cell. Hence, a costly CIN can hit...

Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes.

As part of an effort to dissect the genetic factors involved in cholesterol homeostasis in the mouse model, we report the mapping of 12 new candidate genes using linkage analysis. The genes include: cytoplasmic HMG-CoA synthase (Hmgcs 1, Chr 13), mitochondrial synthase (Hmgcs 2, Chr 3), a synthase-related sequence (Hmgcs 1-rs, Chr 12), mevalonate kinase (Mvk, Chr 5), farnesyl diphosphate syntha...

Mechanisms of Chromosomal Instability

Most solid tumors are aneuploid, having a chromosome number that is not a multiple of the haploid number, and many frequently mis-segregate whole chromosomes in a phenomenon called chromosomal instability (CIN). CIN positively correlates with poor patient prognosis, indicating that reduced mitotic fidelity contributes to cancer progression by increasing genetic diversity among tumor cells. Here...

REGULATION OF ACID-BASE HOMEOSTASIS BY THE KIDNEY